Antimalarial activity of Evolvulus alsinoids Linn.-an in vitro Plasmodium falciparum specific lactate dehydrogenase enzyme inhibition assay
نویسندگان
چکیده
منابع مشابه
Antimalarial Activity of Potential Inhibitors of Plasmodium falciparum Lactate Dehydrogenase Enzyme Selected by Docking Studies
The Plasmodium falciparum lactate dehydrogenase enzyme (PfLDH) has been considered as a potential molecular target for antimalarials due to this parasite's dependence on glycolysis for energy production. Because the LDH enzymes found in P. vivax, P. malariae and P. ovale (pLDH) all exhibit ∼90% identity to PfLDH, it would be desirable to have new anti-pLDH drugs, particularly ones that are effe...
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We have investigated the contribution of drug accumulation and inhibition of heme polymerization to the in vitro activities of a series of antimalarial drugs. Only those compounds exhibiting structural relatedness to the quinolines inhibited heme polymerization. We could find no direct correlation between in vitro activity against chloroquine-susceptible or chloroquine-resistant isolates and ei...
متن کاملStudy of total serum lactate dehydrogenase activity as an indirect evidence of acute Plasmodium falciparum infection
Background : Lactate dehydrogenase (LDH) activity was assayed in the sera of 40 adult male and 40 adult female patients within the age group of 16-50 years presenting with acute, Plasmodium falciparum malaria infection and a control group of 40 healthy adults within the same age group. Study objective: Study was design to determine diagnostic value of serum LDH activity in patient with acute P....
متن کاملPotent Plasmodium falciparum gametocytocidal activity of diaminonaphthoquinones, lead antimalarial chemotypes identified in an antimalarial compound screen.
Forty percent of the world's population is threatened by malaria, which is caused by Plasmodium parasites and results in an estimated 200 million clinical cases and 650,000 deaths each year. Drug resistance has been reported for all commonly used antimalarials and has prompted screens to identify new drug candidates. However, many of these new candidates have not been evaluated against the para...
متن کاملIn Vitro Activity of Mefloquine and its Enantiomers Against Plasmodium falciparum
The in vitro activity of rac-mefloquine hydrochloride and its pure enantiomers was tested against a chloroquine-resistant (PF.IBS2) strain of Plasmodium falciparum. The parasite isolated from Iranian patients was cultured in vitro by the candle jar method described by Tranger and Jensen and was exposed to the racemic mefloquine or its enantiomers over the concentration range of 10-9 to 10-4 M. ...
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ژورنال
عنوان ژورنال: Asian Pacific Journal of Tropical Disease
سال: 2014
ISSN: 2222-1808
DOI: 10.1016/s2222-1808(14)60612-5